Oral Anti-Fungal Medications
For oral treatment of Toenail fungus griseofulvin (Grisactin, Gris-Pegilable was being prescribed from a long time but its use is limited as the necessity of long courses of treatment and high rates decreases its value. The oral form of ketoconazole (Nizoral) is much effective but also there is danger of having the side effect as liver-damage or Onychomycosis. However the results are often disappointing.
In upcoming days, treatment outcomes in patients with Toenail Fungus treatment has improved because of the use of more effective oral antifungal medications. Current reports support the use of individualized treatment plans which consider patient profiles, infecting organism(s), nail characteristics, adjuvant treatments potential drug toxicities and interactions, Triazole and allylamine antifungal drugs have largely replaced griseofulvin and ketoconazole as first-line medications in the treatment of Onychomycosis. But these offer less treatment courses, high rates and also the case relapses. Latest, terbinafine (Lamisil) and itraconazole (Sporanox) are the most widely used, with fluconazole (Diflucan) giving fast and acute results. It’s effectiveness could improve in giving prompt penetration of the nail and nail bed
Against Toenail fungus infection Terbinafine is an antifungal medicine that is active, Adverse side-effects, including headache, rash and gastrointestinal upset, have been reported mostly with terbinafine. Yet, these side effects arenot permanent and resolve with discontinuation of the drug Itraconazole is a new triazole medicine with a broad antifungal spectrum that includes toenail fungus infection. Certain nondermatophytic molds and Candida species. Headache, rash and gastrointestinal disorder are the side-effects, but lever toxicity is very less.Fluconazole is active against common fungal infections, Candida species and some non-dermatophytic molds. Side-effects, including nausea, headache, and liver enzyme abnormalities, have been reported in five percent of treated patients. These side effects vanish after the discontinuationof this medicine.